EuResist Integrated DataBase (EIDB)
The EuResist Integrated DataBase (EIDB) is a multicenter international collection of linked genotypic and clinical information from people living with HIV (PLWH), available for research studies. The EIDB is updated twice a year with longitudinal information from clinical practice dating from 1998 to present.
The EIDB was set up in 2006 within the EU funded project “EuResist” to develop the machine learning based EuResist Prediction System. Since then it has grown-up to become one of the largest existing clinical-genotypic data sets available for monitoring the selection, transmission and clinical relevance of HIV drug resistance as well as for realising artificial intelligence based tools to support clinical practice based on real world data.
Main info fields collected in the EIDB:
Demographics (including naïve status) • Antiviral therapy • AIDS defining events • CD4 measurements • Viral Load measurements • HIV sequences
As of the latest update, the EIDB contains the data illustrated below from over 115.800 patients.
CD4
1.628.138
Viral Load
1.562.581
Treatment Regimens
267.112
Raw Sequences
112.257
The EIDB is open for scientific studies under approval of the Scientific Board and adherence to the EuResist Authorship Policy (link).
You are invited to submit a study proposal using the EuResist Study template.
Genotypes and lab values
Treatments
Mutations
HIV sequences
EIDB history and data contributors
The EIDB was born in 2006 from the three founding national databases:
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ARCA database (Italy),
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AREVIR database (Germany)
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Karolinska Institute (Sweden)
Following the EIDB setup, other centers and studies contributed their data:
Instituto de Higiene e Medicina Tropical (Portugal); irsiCaixa Foundation (Spain); the Rega Institute (Belgium); Laboratoire de Rétrovirologie of CRP-Santé (Luxembourg); the DUET study by Tibotec; the RESIST study by Boheringer Ingelheim; the National Referral Laboratory of Rwanda; the Ivanovsky Institute of virology – Gamaleya centre (Russia); Koacaeli University Medical Faculty (Turkey), CoRIS cohort (Spain).
As of 2022, the following centres provide continuously updated data to the EIDB:
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ARCA (Italy)
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AREVIR (Germany)
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Karolinska Institute (Sweden)
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Instituto de Higiene e Medicina Tropical (Portugal)
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Laboratoire de Rétrovirologie of CRP-Santé (Luxembourg)
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Ivanovsky Institute of virology (Russia)
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Koacaeli University Medical Faculty (Turkey)
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CoRIS cohort (Spain)
How to contribute to the data base
You can contribute your data to the EuResist initiative and have the possibility to query the whole data set for study proposals (upon request). Contribution is regulated by a contract. The general rules for participation are as follows.
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Data provided by external contributors are provided solely for development of the treatment response models (i.e. the focus of the EuResist project); any other use is subject to information to and explicit approval by the contributing center;
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The task of integrating new data into the EIDB will be carried out by EuResist with the collaboration of the data provider, limited to providing information on database platform and schema and sending data via the method agreed upon. Integrating data ensures a quality control made by the EIDB administrator at the advantage of the contributing center;
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The co-authorship policy reserves one slot for each data provider in each scientific paper and congress presentation provided this is in-line with the journal editorial policy in terms of limitation in the number of authors or kind of work performed;
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Data contributed remain the property of the contributing center for ever. The data provider reserves the right to have its data permanently removed from EIDB at any moment without any need to justify this decision. Should this occur, the data are considered available only for pending papers explicitly agreed upon, i.e. being submitted for publication;
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Should EuResist end, each external dataset will be removed from the EIDB unless the contributing center explicitly requests that the data remain in the EIDB
